As I know you are a "power" user who will push his machine hard, and you have mentioned a lot of your usage will be work (with some play), I would suggest purchasing a proper workstation pc as opposed to a generic desktop/tower or build your own.
As examples of what I mean, look into the Dell Precision range or HP (I think their workstations are called Z series).
I know they cost more than a lot of comparable desktops, but they are built and evaluated for serious use.
Just as an example, I'm still running a top end Dell Precision that was made around 2010 and even though I know I have had a defective DIMM for over a year it still never crashes, and I get a lot less "random" crashes then I did with a normal/non workstation pc.
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