The official summary from Fox:
After engineering an escape from the hellish Panamanian prison Sona, brothers Michael Scofield and Lincoln Burrows are determined to seek justice against The Company, the shadowy group responsible for destroying their lives and killing the woman Michael loves, Dr. Sara Tancredi. During their quest for vengeance, Michael’s world is turned upside down when he learns that Sara is still alive. Realizing the only way they will truly be free, Michael and Lincoln avenge to find Sara and take down The Company. With the help of a government handler, they assemble a group of allies and familiar faces including Mahone, Sucre and Bellick to aid in their seemingly impossible task. Unfortunately for the brothers, they must also enlist T-Bag, who unknowingly possesses a vital clue to help them pull off their most difficult challenge yet. They’ll soon discover the only thing harder than breaking out is breaking in.
Cast: Dominic Purcell as Lincoln Burrows, Wentworth Miller as Michael Scofield, William Fichtner as Alexander Mahone, Amaury Nolasco as Fernando Sucre, Wade Williams as Brad Bellick, Robert Knepper as T-Bag, Sarah Wayne Callies as Dr. Sara Tancredi, Chris Vance as James Whistler, Jodi Lyn O’Keefe as Susan B. Anthony, Danay Garcia as Sofia.
nicked from eztv